Changes in Pattern and Multifocal Electroretinogram in Tuberculosis Patient with Ethambutol Therapy

Introduction: Tuberculosis (TB) is a world health problem, especially in Indonesia as the third biggest country for new emerging TB patients. Ethambutol one of standard therapies to treat patients Indonesia. has side effect called ethambutol optic neuropathy which hard diagnose due normal fundus appearance most cases and therefore often detected late. Early detection necessary so that permanent damage can be prevented. Examination pattern electroretinography (pERG) multifocal (mfERG) have advantage detect confirm ocular toxicity by after clinical problem had emerged. It not yet known neither pERG nor mfERG could any changes before Methods: This study was prospective trial with 40 eyes samples analyzed paired t Wilcoxon tests. The examination conducted using Snellen chart, HRR Richmond Plates, Pelli Robson, pERG, tuberculosis category 1 patient 2 months follow-up. Result: Visual acuity, color, contrast sensitivity were all follow-up period. In examination, mean implicit time wave P50 shortened -1.27± 4.71 mS (p=0.049), amplitude N95 reduced -0.93± 4.49 ?V (p=0.038). Both statistically significant. we did find significant both N1 P1. Conclusion: Changes ERG presented earlier compared therapy months.